Brouilhet H, Rabaud M, Boucherie S, Mach P S, Delbarre F, Dryll A
Biomed Pharmacother. 1982;36(6-7):297-302.
The effect of D. Penicillamine (DP) at the dose of 50 mg/kg/day, on an immune induced connective tissue disease in rabbit, is compared to that of dexamethasone (Dexa) at the doses of 0.15 and 0.075 mg/kg/day. This model includes polyarthritis and lesions of connective tissue of liver, kidneys and lungs. The result of immunization is initially a non-specific macrophage infiltration and secondarily a specific lymphocyte and plasma-cell infiltration. In short treatment, high dose of Dexa inhibits the non-specific and specific responses while DP modifies only non specific response. In long treatment, Dexa at low dose and DP inhibit the two responses. Data suggest that, in vivo, macrophages is the target cell of DP.
将50毫克/千克/天剂量的青霉胺（DP）对兔免疫诱导的结缔组织疾病的影响，与0.15毫克/千克/天和0.075毫克/千克/天剂量的地塞米松（Dexa）的影响进行比较。该模型包括多关节炎以及肝脏、肾脏和肺部结缔组织的病变。免疫的结果最初是非特异性巨噬细胞浸润，其次是特异性淋巴细胞和浆细胞浸润。在短期治疗中，高剂量的地塞米松抑制非特异性和特异性反应，而青霉胺仅改变非特异性反应。在长期治疗中，低剂量的地塞米松和青霉胺抑制这两种反应。数据表明，在体内，巨噬细胞是青霉胺的靶细胞。
