Van Dijk H, Voermans G A
Immunology. 1978 Jun;34(6):1077-81.
The possible immunostimulating effect of 6-thioguanine was studied in the mouse. It caused a dose-dependent suppression of the cellular and humoral immune response if administered 1 day before immunization. If, however, the interval between 6-thioguanine administration and immunization was extended to 5 days, a significant enhancement of delayed hypersensitivity was observed. The The enhancement occurred only after immunization with 10(6) and 10(7) sheep red cells. The analogy between the immunostimulating effects of 6-thioguanine and cyclophosphamide is discussed.
在小鼠中研究了6-硫鸟嘌呤可能的免疫刺激作用。如果在免疫前1天给药,它会引起细胞免疫和体液免疫反应的剂量依赖性抑制。然而,如果将6-硫鸟嘌呤给药与免疫之间的间隔延长至5天,则观察到迟发型超敏反应显著增强。这种增强仅在用10(6)和10(7)个绵羊红细胞免疫后出现。讨论了6-硫鸟嘌呤和环磷酰胺免疫刺激作用之间的相似性。