Grant B J
J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1330-7. doi: 10.1152/jappl.1982.52.5.1330.
The influence of the Bohr-Haldane effect (BH) on steady-state gas exchange has previously been described by its effect of gas transfer from the blood when arterial and venous blood gas tensions were held constant. This report quantifies by computer analysis the effects of BH when either or both arterial and venous blood gas tensions are subject to change. When mixed venous blood gas composition is held constant, elimination of BH from a single lung unit typically reduces CO2 output by 6.5% and O2 uptake by 0.5%. Similar effects occur in a two-compartment lung model whether alveolar ventilation-perfusion (VA/Q) mismatch occurs in a parallel or series ventilatory arrangement. When arterial blood gas composition is held constant, elimination of BH increases systemic venous CO2 partial pressure, but O2 partial pressure is hardly affected in the absence of metabolic acidosis. When both mixed venous and arterial blood gas tensions vary and gas exchange is stressed by VA/Q inequality, altitude, anemia, or exercise, elimination of BH predominantly affects mixed venous rather than arterial blood gas tensions. it is concluded that BH may act primarily to reduce tissue acidosis.
玻尔 - 哈代效应（BH）对稳态气体交换的影响，此前已通过在动脉和静脉血气张力保持恒定时其对血液气体转移的作用进行了描述。本报告通过计算机分析量化了当动脉和静脉血气张力一方或双方发生变化时BH的影响。当混合静脉血气成分保持恒定时，从单个肺单位消除BH通常会使二氧化碳排出量减少6.5%，氧气摄取量减少0.5%。在双室肺模型中，无论肺泡通气 - 灌注（VA/Q）不匹配是发生在平行还是串联通气排列中，都会出现类似的效果。当动脉血气成分保持恒定时，消除BH会增加体循环静脉二氧化碳分压，但在没有代谢性酸中毒的情况下，氧分压几乎不受影响。当混合静脉和动脉血气张力都发生变化且气体交换因VA/Q不平等、高原、贫血或运动而受到压力时，消除BH主要影响混合静脉血气张力而非动脉血气张力。得出的结论是，BH可能主要起到减少组织酸中毒的作用。
