雌二醇对去势男性促黄体生成素对促性腺激素释放激素反应的双相作用。

Biphasic effect of estradiol on luteinizing hormone response to gonadotropin-releasing hormone in castrated men.

作者信息

Barbarino A, De Marinis L, Mancini A, Giustacchini M, Alcini A E

出版信息

Metabolism. 1982 Aug;31(8):755-8. doi: 10.1016/0026-0495(82)90071-3.

Abstract

This study was designed to investigate the possibility that in men estradiol (E2) has a stimulatory effect on the gonadotropin response to GnRH. Nine castrated adult men, who presented extremely low testosterone (T) concentrations, received 5 mg/day estradiol benzoate (E2B) i.m. every 24 hr for several days, starting 5 days after orchidectomy. During E2B treatment the pituitary responsiveness to GnRH (100 micrograms given as an iv bolus) was tested after 24, 48, 72, 96, 120, and 144 hrs of E2B administration. The pituitary responsiveness to GnRH was also tested in untreated men from day 5 to day 10 following bilateral orchidectomy. In the E2B-treated subjects the increased serum estradiol concentrations induced an initial decrease and a subsequent increase of the LH response to GnRH. The responses were decreased after 24 hr of treatment; thereafter, the LH responses were progressively increased and were markedly augmented after 120 hr of E2B treatment. On the contrary, during treatment the FSH response to GnRH was preferentially blunted. In the untreated castrated men the LH and FSH responses to GnRH increased progressively from day 5 to day 10 after orchidectomy, but decreased responses were never observed during this period of observation. The maximum LH concentrations, which occurred at 30-60 min following GnRH in untreated castrated men, did not occur until 120-150 min in the E2B treated men.

摘要

本研究旨在探讨在男性中雌二醇（E2）对促性腺激素对促性腺激素释放激素（GnRH）反应具有刺激作用的可能性。9名成年去势男性，其睾酮（T）浓度极低，在睾丸切除术后5天开始，每24小时肌肉注射5毫克苯甲酸雌二醇（E2B），持续数天。在E2B治疗期间，在给予E2B 24、48、72、96、120和144小时后，测试垂体对GnRH（静脉推注100微克）的反应性。在双侧睾丸切除术后第5天至第10天，也对未治疗的男性进行垂体对GnRH反应性的测试。在接受E2B治疗的受试者中，血清雌二醇浓度升高导致促黄体生成素（LH）对GnRH反应先降低后升高。治疗24小时后反应降低；此后，LH反应逐渐增加，在E2B治疗120小时后显著增强。相反，在治疗期间，促卵泡生成素（FSH）对GnRH的反应优先受到抑制。在未治疗的去势男性中，LH和FSH对GnRH的反应在睾丸切除术后第5天至第10天逐渐增加，但在此观察期间未观察到反应降低的情况。未治疗的去势男性在GnRH注射后30 - 60分钟出现的最大LH浓度，在接受E2B治疗的男性中直到120 - 150分钟才出现。