Weyne J, Nshimyumuremyi J B, Demeester G, Leusen I
Pflugers Arch. 1982 Apr;393(2):157-63. doi: 10.1007/BF00582939.
In anesthetized normocapnic dogs CSF [HCO(-3)] was increased to 33 mmol/l by perfusing the brain ventricles for 45 min with a mock CSF containing a high [HCO(-3)]. In dogs with normal plasma [HCO(-3)], CSF [HCO(-3)]fell by ca. 7 mmol/l in 2 h following the end of the perfusion. Lowering plasma [HCO(-3)] to 11 mmol/l by infusing HCl intravenously was without effect but increasing plasma [HCO(-3)] to 36 mmol/l by infusing Na2CO3 limited the CSF [HCO(-3)] fall to 2.8 mmol/l. It is concluded that correction of CSF [HCO(-3)] is partially dependent on a sufficiently low plasma [HCO(-3)]. The small and persistent fall of CSF [HCO(-3)] which at high plasma [HCO(-3)] occurs against a concentration gradient with blood suggests moreover the contribution of more specific mechanism(s) for lowering CSF [HCO(-3)] after its experimental increase.
在麻醉状态下的正常碳酸血症犬中，通过用含有高浓度[HCO₃⁻]的模拟脑脊液灌注脑室45分钟，使脑脊液[HCO₃⁻]升高至33 mmol/L。在血浆[HCO₃⁻]正常的犬中，灌注结束后2小时内，脑脊液[HCO₃⁻]大约下降7 mmol/L。通过静脉输注HCl将血浆[HCO₃⁻]降至11 mmol/L没有效果，但通过输注Na₂CO₃将血浆[HCO₃⁻]升至36 mmol/L可使脑脊液[HCO₃⁻]的下降限制在2.8 mmol/L。结论是，脑脊液[HCO₃⁻]的校正部分依赖于足够低的血浆[HCO₃⁻]。此外，在高血浆[HCO₃⁻]时，脑脊液[HCO₃⁻]会逆着与血液的浓度梯度发生微小且持续的下降，这表明在实验性升高后，存在更特殊的机制来降低脑脊液[HCO₃⁻]。
