Michelassi F, Landa L, Hill R D, Lowenstein E, Watkins W D, Petkau A J, Zapol W M
Science. 1982 Aug 27;217(4562):841-3. doi: 10.1126/science.6808665.
Leukotriene D4 (2 c 10(-9) mole), injected into the left circumflex coronary artery of anesthetized sheep, produced profound coronary vasoconstriction and impaired regional ventricular wall motion. This cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor nor associated with thromboxane B2 release into the coronary sinus. Intravenous FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D4, but a significant reduction of regional wall shortening persisted.
将白三烯D4（2×10⁻⁹摩尔）注入麻醉绵羊的左回旋冠状动脉，可产生严重的冠状动脉收缩并损害局部心室壁运动。这种心脏效应既不被事先用环氧化酶抑制剂处理绵羊所抑制，也与血栓素B2释放到冠状窦无关。静脉注射FPL 55712可完全消除白三烯D4引起的冠状动脉收缩，但局部壁缩短仍显著降低。
