Boyd L M, Ezra D, Feuerstein G, Goldstein R E
Eur J Pharmacol. 1983 May 6;89(3-4):307-11. doi: 10.1016/0014-2999(83)90512-5.
Intracoronary leukotriene D4, 0.1-3.0 micrograms (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 micrograms leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations in coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.
冠状动脉内注射白三烯D4（0.1 - 3.0微克，即0.2 - 6.0纳摩尔）可使麻醉猪的冠状动脉血流量呈剂量依赖性减少。冠状动脉内预先注射FPL - 55712（0.1、0.3和1.0毫克）可使由1.0微克白三烯D4引起的冠状动脉收缩减少达77%。FPL - 55712不会对冠状动脉血流量、左心室舒张末期压力、体动脉血压或心率产生持续性改变。预先静脉注射消炎痛（6毫克/千克）对白三烯诱导的冠状动脉收缩没有影响。FPL - 55712产生的抑制作用可能对涉及白三烯介导的冠状动脉收缩的疾病状态有用。
