Kihlström I
Acta Pharmacol Toxicol (Copenh). 1982 Apr;50(4):300-4. doi: 10.1111/j.1600-0773.1982.tb00977.x.
Placental transport of 2,2',4,4',5,5'-hexachlorobiphenyl in the guinea-pig was studied by means of perfusion technique. This transfer was rapid when heparinized blood was used as perfusion medium. The same concentration of the chlorobiphenyl in both maternal and foetal compartments was achieved about 20 min. after start of infusion. It was also shown that when dextran solution or dextran solution with addition of Intralipid to the same concentration as the total lipid concentration in blood, were used as perfusion medium, there was no placental transport of the chlorobiphenyl. Furthermore, it was shown that the placental transport of the chlorobiphenyl was strongly dependent on the albumin concentration, but independent of the gamma-globulin concentration in the perfusion medium.
采用灌注技术研究了豚鼠体内2,2',4,4',5,5'-六氯联苯的胎盘转运。当使用肝素化血液作为灌注介质时，这种转运很快。输注开始后约20分钟，母体和胎儿隔室中的氯联苯浓度达到相同水平。研究还表明，当使用葡聚糖溶液或添加了与血液中总脂质浓度相同浓度的脂质乳剂的葡聚糖溶液作为灌注介质时，氯联苯没有胎盘转运。此外，研究表明，氯联苯的胎盘转运强烈依赖于灌注介质中的白蛋白浓度，但与γ-球蛋白浓度无关。
