妊娠及相关情况对大鼠实验性关节炎的作用（作者译）
[Role of pregnancy and related conditions on experimental arthritis of the rat (author's transl)].
作者信息
Delbarre F, de Gery A, Kahan A, Na P
出版信息
C R Seances Acad Sci III. 1982 May 3;294(16):799-804.
Pregnancy in Rat induces, as in humans suffering from rheumatoid arthritis, a striking improvement of adjuvant arthritis. This improvement is not associated with an enhancement of corticosteronemia; it does not appear either in pseudo-pregnancy, or in experimental deciduoma. It could rather be related to an immune mechanism; an enhancement of T suppressor lymphocytes associated to a decrease of T helper lymphocyte activity in peripheral blood as suggested by a high response to ConA and low response PHA and PWM during arthritis plus pregnancy. The influence of hormonal factors on recirculation and/or activity of peripheral lymphocytes is not excluded.
与患类风湿性关节炎的人类一样，大鼠怀孕会使佐剂性关节炎显著改善。这种改善与皮质酮血症的增强无关；在假孕或实验性蜕膜瘤中也未出现。它可能与免疫机制有关；如在关节炎加怀孕期间对刀豆蛋白A反应高、对植物血凝素和美洲商陆丝裂原反应低所表明的那样，外周血中T抑制淋巴细胞增多，同时T辅助淋巴细胞活性降低。并不排除激素因素对外周淋巴细胞再循环和/或活性的影响。
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