使用渗透微型泵输送甲状旁腺激素。
Use of osmotic minipumps for delivery of parathyroid hormone.
作者信息
Hock J M, Simmons H A, Schiess M C, Raisz L G
出版信息
Calcif Tissue Int. 1982 May;34(3):270-2. doi: 10.1007/BF02411249.
PMID:6809288
Abstract
To determine if osmotic minipumps can be used for the local delivery of parathyroid hormone (PTH), we examined the bone resorbing activity of PTH in minipumps, either removed and assayed in bone organ cultures or released over rat calvaria. Biological activity of PTH was maintained for up to 6 days when the hormone solution contained serum and the minipumps and tubing were siliconized and flushed with diluent prior to use. Addition of cysteine did not enhance activity.
摘要
为了确定渗透微型泵是否可用于甲状旁腺激素（PTH）的局部递送，我们检测了微型泵中PTH的骨吸收活性，该活性可在骨器官培养中取出并测定，也可在大鼠颅骨上释放。当激素溶液含有血清，且微型泵和管道在使用前进行硅化并用稀释剂冲洗时，PTH的生物活性可维持长达6天。添加半胱氨酸并不能增强活性。
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