Popp M B, Morrison S D, Brennan M F
Cancer Treat Rep. 1981;65 Suppl 5:137-43.
Problems with currently available studies of the effects of total parenteral nutrition (TPN) on rat tumor models include: inadequate definition of the natural history of the tumor model; use of nutritional techniques and solutions which have not been proven effective; failure to allow animals to recover from stress of catheterization before starting nutritional manipulation; short-term studies; failure to use sham-operated orally fed control animals; and inadequate evaluation of nutritional result. We have instituted TPN after a 4-day postcatheterization recovery period in a defined methylcholanthrene-induced rat sarcoma model. Preliminary results suggest that TPN increases tumor weight without changing tumor composition of water, nitrogen, or fat. TPN also increases carcass fat and water content, but not carcass protein. In tumor-bearing animals, the percentage of energy expended on activity decreases with increasing tumor burden in both TPN and orally fed controls. TPN in these studies appears to support fat stores and stimulate tumor growth.
目前关于全胃肠外营养（TPN）对大鼠肿瘤模型影响的研究存在以下问题：肿瘤模型自然史的定义不充分；使用未经证实有效的营养技术和溶液；在开始营养操作前未让动物从插管应激中恢复；短期研究；未使用假手术经口喂养的对照动物；以及营养结果评估不充分。在一个明确的甲基胆蒽诱导的大鼠肉瘤模型中，我们在插管后4天的恢复期后开始实施TPN。初步结果表明，TPN增加了肿瘤重量，但未改变肿瘤的水、氮或脂肪组成。TPN还增加了胴体脂肪和水分含量，但未增加胴体蛋白质。在荷瘤动物中，无论是TPN组还是经口喂养的对照组，随着肿瘤负荷增加，用于活动的能量百分比均下降。这些研究中的TPN似乎支持脂肪储存并刺激肿瘤生长。
