Dixit V P, Jain H C, Sharma A N, Bhargava S K, Sandhu J S
Indian J Physiol Pharmacol. 1978 Jan-Mar;22(1):82-6.
1-Cyproterone acetate administration (0.2 mg/day/animal for 25 days) caused widespread testicular necrosis. The lumen of the epididymides were devoid of spermatozoa. The RNA, protein, sialic acid and phosphatase enzyme activity of the testes were reduced. Serum transaminase enzyme activity was slightly changed. Haemoglobin, hematocrit, blood sugar, and blood urea levels were in the normal range. Regressed Leydig cell tissue and decreased production of RNA and sialic acid in the testes could be due to the antiandrogenic action produced by cyproterone acetate.
给予醋酸环丙孕酮（0.2毫克/天/只动物，持续25天）会导致广泛的睾丸坏死。附睾管腔内没有精子。睾丸的RNA、蛋白质、唾液酸和磷酸酶活性降低。血清转氨酶活性略有变化。血红蛋白、血细胞比容、血糖和血尿素水平在正常范围内。睾丸中Leydig细胞组织退化以及RNA和唾液酸产生减少可能是由于醋酸环丙孕酮产生的抗雄激素作用。
