钙和钙离子载体A23187可改变大鼠乳腺腺泡的蛋白质合成和分泌。
Calcium and calcium ionophore A23187 alter protein synthesis and secretion by acini from rat mammary gland.
作者信息
Smith J J, Park C S, Keenan T W
出版信息
Int J Biochem. 1982;14(7):573-6. doi: 10.1016/0020-711x(82)90038-6.
PMID:6809507
Abstract
- Acini (alveoli) from lactating rat mammary gland responded to increasing levels of calcium or calcium ionophore A23187 with increased protein synthesis and secretion. 2. Inclusion of dibutyryl cyclic AMP in incubation medium with calcium or calcium ionophore decreased protein synthesis but increased rate of protein secretion . 3. Calcium ionophore increased both rates of calcium uptake by acini and levels of intracellular calcium. 4. These results suggest a relationship between calcium and cyclic AMP in milk protein synthesis and secretion.
摘要
- 来自泌乳大鼠乳腺的腺泡（肺泡）对钙或钙离子载体A23187水平的升高作出反应，蛋白质合成和分泌增加。2. 在含有钙或钙离子载体的孵育培养基中加入二丁酰环磷腺苷会降低蛋白质合成，但会提高蛋白质分泌速率。3. 钙离子载体增加了腺泡对钙的摄取速率和细胞内钙水平。4. 这些结果表明钙和环磷腺苷在乳蛋白合成和分泌之间存在关联。
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