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钙和钙离子载体A23187可改变大鼠乳腺腺泡的蛋白质合成和分泌。

Calcium and calcium ionophore A23187 alter protein synthesis and secretion by acini from rat mammary gland.

作者信息

Smith J J, Park C S, Keenan T W

出版信息

Int J Biochem. 1982;14(7):573-6. doi: 10.1016/0020-711x(82)90038-6.

DOI:10.1016/0020-711x(82)90038-6
PMID:6809507
Abstract
  1. Acini (alveoli) from lactating rat mammary gland responded to increasing levels of calcium or calcium ionophore A23187 with increased protein synthesis and secretion. 2. Inclusion of dibutyryl cyclic AMP in incubation medium with calcium or calcium ionophore decreased protein synthesis but increased rate of protein secretion . 3. Calcium ionophore increased both rates of calcium uptake by acini and levels of intracellular calcium. 4. These results suggest a relationship between calcium and cyclic AMP in milk protein synthesis and secretion.
摘要
  1. 来自泌乳大鼠乳腺的腺泡（肺泡）对钙或钙离子载体A23187水平的升高作出反应，蛋白质合成和分泌增加。2. 在含有钙或钙离子载体的孵育培养基中加入二丁酰环磷腺苷会降低蛋白质合成，但会提高蛋白质分泌速率。3. 钙离子载体增加了腺泡对钙的摄取速率和细胞内钙水平。4. 这些结果表明钙和环磷腺苷在乳蛋白合成和分泌之间存在关联。

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Calcium and calcium ionophore A23187 alter protein synthesis and secretion by acini from rat mammary gland.钙和钙离子载体A23187可改变大鼠乳腺腺泡的蛋白质合成和分泌。
Int J Biochem. 1982;14(7):573-6. doi: 10.1016/0020-711x(82)90038-6.
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The effect of intracellular calcium ions on adrenaline-stimulated adenosine 3':5'-cyclic monophosphate concentrations in pigeon erythrocytes, studied by using the ionophore A23187.通过使用离子载体A23187研究细胞内钙离子对鸽红细胞中肾上腺素刺激的3':5'-环磷酸腺苷浓度的影响。
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引用本文的文献

1
Calcium-ion and calmodulin-dependent kappa-casein kinase in rat mammary acini.大鼠乳腺腺泡中的钙离子和钙调蛋白依赖性κ-酪蛋白激酶
Biochem J. 1984 Nov 15;224(1):195-200. doi: 10.1042/bj2240195.
2
Proteins are secreted by both constitutive and regulated secretory pathways in lactating mouse mammary epithelial cells.蛋白质通过组成型和调节型分泌途径在泌乳小鼠乳腺上皮细胞中分泌。
J Cell Biol. 1992 Apr;117(2):269-78. doi: 10.1083/jcb.117.2.269.