Kelly R H, Hardy T J
Int Arch Allergy Appl Immunol. 1982;69(1):56-61. doi: 10.1159/000233146.
Diseases associated with multiple clonally-restricted serum immunoglobulin (Ig) abnormalities present at levels which, in most cases, preclude detection by conventional immunoelectrophoresis, were studied using methods for detection and characterization of homogeneous Ig that are approximately equal to 40 times more sensitive than either cellulose acetate zone electrophoresis or immunoelectrophoresis. Patients with these Ig abnormalities had a high incidence of infectious disease (29% of total cases), malignancy (19%), connective tissue disease (14%) and liver disease (10%). The concentration of individual clonal products was found to wax and wane, but it could not be determined whether these clonally-restricted Ig species represent, wholly or in part, the products of dominant antibody-producing plasma cell clones involved in the patients' response to their disease. We conclude that multiple homogeneous serum Ig abnormalities occur in clinical situations where heightened antigenic stimulation and/or immune reactivity are thought to occur (e.g., infections, malignancies and autoimmunity). Laboratory evaluation of these Ig abnormalities could be useful for diagnostic and/or therapeutic monitoring purposes in situations where the specificity of the clonally-restricted Ig species can be established.
研究了与多种克隆性受限血清免疫球蛋白（Ig）异常相关的疾病，这些异常在大多数情况下以常规免疫电泳无法检测到的水平存在。采用检测和鉴定均质Ig的方法对其进行研究，这些方法的灵敏度比醋酸纤维素区带电泳或免疫电泳高约40倍。患有这些Ig异常的患者传染病发病率高（占总病例的29%）、恶性肿瘤（19%）、结缔组织病（14%）和肝病（10%）。发现单个克隆产物的浓度有波动，但无法确定这些克隆性受限的Ig种类是否全部或部分代表参与患者对疾病反应的主要抗体产生浆细胞克隆的产物。我们得出结论，在认为存在抗原刺激增强和/或免疫反应性增强的临床情况（如感染、恶性肿瘤和自身免疫）中会出现多种均质血清Ig异常。在能够确定克隆性受限Ig种类特异性的情况下，对这些Ig异常进行实验室评估可能有助于诊断和/或治疗监测。
