一系列亚生育男性的细胞遗传学和组织学研究。

Cytogenetic and histological studies in a series of subfertile males.

作者信息

Curtis D, Thomas A, Williams J L, Lenton E, Cooke I D

出版信息

Int J Androl. 1982 Apr;5(2):113-29. doi: 10.1111/j.1365-2605.1982.tb00239.x.

DOI:10.1111/j.1365-2605.1982.tb00239.x

Abstract

Cytogenetic and histological studies were carried out on a series of 68 men during investigations for subfertility. Somatic chromosome analysis identified 4 cases with abnormal karyotypes. Meiotic chromosome analysis identified 4 cases with abnormal meiosis. Analysis of cell stages of the spermatogenic cycle in cytogenetic preparations identified 12 cases with missing cell cycle stages. Histological analysis of tissue samples identified defects of the spermatogenic cycle in 23 cases. A kinetic model of spermatogenesis is used in order to relate the different types of abnormality to the spermatogenic cycle.

摘要

在对68名男性进行不育症调查期间，开展了细胞遗传学和组织学研究。体细胞染色体分析鉴定出4例核型异常的病例。减数分裂染色体分析鉴定出4例减数分裂异常的病例。细胞遗传学制片中生精周期细胞阶段分析鉴定出12例存在细胞周期阶段缺失的病例。组织样本的组织学分析鉴定出23例存在生精周期缺陷的病例。运用了一个精子发生动力学模型，以便将不同类型的异常与生精周期联系起来。