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生育能力正常和生育能力低下男性精子发生的比较研究。

Comparative studies of spermatogenesis in fertile and subfertile men.

作者信息

Lamont M A, Faed M J, Baxby K

出版信息

J Clin Pathol. 1981 Feb;34(2):145-50. doi: 10.1136/jcp.34.2.145.

DOI:10.1136/jcp.34.2.145
PMID:7229093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1146440/
Abstract

Testicular biopsy specimens from 16 fertile and 10 subfertile men with normal male karyotype were studied quantitatively to provide histological and cytogenetic data for a basis of reference in assessing abnormalities of spermatogenesis. Histological studies included estimation of the proportion and activity of germinal epithelium and an assessment of tubular morphology. In cytogenetic preparations, counts were made of cells at different stages of meiosis. Studies of cells at diakinesis included chiasma counts and percentage of cells with dissociated sex chromosomes. One fertile and six subfertile men showed decreased germinal activity; the six subfertile men also had decreased MII/MI ratios. Other findings were similar in the two groups.

摘要

对16名具有正常男性核型的生育能力正常的男性和10名生育能力低下的男性的睾丸活检标本进行了定量研究，以提供组织学和细胞遗传学数据，作为评估精子发生异常的参考依据。组织学研究包括对生精上皮比例和活性的估计以及对曲细精管形态的评估。在细胞遗传学标本中，对减数分裂不同阶段的细胞进行了计数。对终变期细胞的研究包括交叉计数和性染色体分离细胞的百分比。一名生育能力正常的男性和六名生育能力低下的男性显示出生精活性降低；这六名生育能力低下的男性的减数第二次分裂/减数第一次分裂（MII/MI）比率也降低。两组的其他发现相似。

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Arch Toxicol. 1993;67(2):131-40. doi: 10.1007/BF01973684.
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Cytogenetic and histological studies of testicular biopsies from subfertile men with chromosome anomaly.对患有染色体异常的亚生育男性睾丸活检组织进行的细胞遗传学和组织学研究。
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本文引用的文献

1
AN AIR-DRYING METHOD FOR MEIOTIC PREPARATIONS FROM MAMMALIAN TESTES.一种用于制备哺乳动物睾丸减数分裂标本的空气干燥法。
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Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males.睾丸活检评分计数——一种记录人类睾丸生精功能的方法：335例性腺功能减退男性的正常值及结果
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Observer disagreement in the classification and histology of Hodgkin's disease.霍奇金淋巴瘤分类及组织学方面的观察者间分歧
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The frequency and distribution of chiasmata in man.人类交叉的频率与分布
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Quantification of human seminiferous epithelium. 3. Histological studies in 44 infertile men with normal chromosome complements.人类生精上皮的定量分析。3. 对44名染色体组型正常的不育男性进行的组织学研究。
Acta Pathol Microbiol Scand A. 1973 Mar;81(2):97-111.
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Centromere staining at meiosis in man.人类减数分裂时的着丝粒染色。
Humangenetik. 1973 May 25;18(3):247-52. doi: 10.1007/BF00290604.
10
Cytogenetics and infertility in man. II. Testicular histology and meiosis.人类细胞遗传学与不育症。II. 睾丸组织学与减数分裂。
Ann Hum Genet. 1976 Nov;40(2):165-76. doi: 10.1111/j.1469-1809.1976.tb00176.x.

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