Valladares B K, Lemberg L
Heart Lung. 1982 Sep-Oct;11(5):490-3.
Intravenous nitroglycerin is helpful as an adjunct to the judicious use of diuretics in the management of CHF complicating an acute MI. The clinical end point when using intravenous nitroglycerin is a reduced LVEDP, 16 mm Hg, measured either by PA diastolic pressure or PCWP, provided peripheral perfusion is not compromised, i.e., as blood pressure adequate for peripheral needs (absence of signs of hypovolemic shock). The reduction in cardiac work plus the improvement in coronary flow to the ischemic area can help reduce infarct size, especially if intravenous nitroglycerin is started within the first 6 hours of the onset of an acute MI.
静脉注射硝酸甘油有助于在急性心肌梗死并发心力衰竭的治疗中，作为合理使用利尿剂的辅助手段。使用静脉注射硝酸甘油时的临床终点是左心室舒张末期压力（LVEDP）降低至16 mmHg，可通过肺动脉舒张压或肺毛细血管楔压来测量，前提是外周灌注不受影响，即血压足以满足外周需求（无低血容量性休克体征）。心脏做功的减少以及缺血区域冠状动脉血流的改善有助于缩小梗死面积，特别是在急性心肌梗死发病后的头6小时内开始静脉注射硝酸甘油时。
