Song C W, Lee C K, Rhee J G, Levitt S H
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):749-52. doi: 10.1016/0360-3016(82)90727-1.
The cytotoxicity of 5-thio-D-glucose (5-TG) and misonidazole (MISO) on hypoxic cells in vitro was compared, and the combined effect of these two compounds was investigated. The cytotoxicity of 5-TG on hypoxic SCK mammary carcinoma cells of mice was markedly greater than that of MISO. However, MISO was more toxic than was 5-TG to P815-X2 mastocytoma cells of mice. The elevation of temperature from 37.5 degrees C to 40.0 degrees C during incubation with drugs greatly enhanced the cell death. The thermal enhancement of cytotoxicity of 5-TG to mastocytoma cells appeared to be greater than that of MISO. Preliminary studies indicated that the combined effect of 5-TG and MISO is additive, suggesting the intracellular targets or cytocidal mechanisms of these two compounds may be different.
比较了5-硫代-D-葡萄糖（5-TG）和米索硝唑（MISO）对体外缺氧细胞的细胞毒性，并研究了这两种化合物的联合作用。5-TG对小鼠缺氧SCK乳腺癌细胞的细胞毒性明显大于MISO。然而，MISO对小鼠P815-X2肥大细胞瘤细胞的毒性比5-TG更大。药物孵育期间温度从37.5℃升高到40.0℃极大地增强了细胞死亡。5-TG对肥大细胞瘤细胞的细胞毒性热增强似乎大于MISO。初步研究表明，5-TG和MISO的联合作用是相加的，这表明这两种化合物的细胞内靶点或杀细胞机制可能不同。
