Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells.
作者信息
Song C W, Clement J J, Levitt S H
出版信息
J Natl Cancer Inst. 1976 Sep;57(3):603-5. doi: 10.1093/jnci/57.3.603.
PMID:824455
Abstract
5-Thio-D-glucose effectively killed hypoxic mastocytoma cells of DBA/2J mice, whereas it merely suppressed the growth of oxic cells. This specific toxicity suggested that 5-thio-D-glucose may be a useful adjuvant to radiotherapy by eliminating hypoxic protection.
摘要
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