早期胰岛素依赖型糖尿病患者中51铬-乙二胺四乙酸、对氨基马尿酸和葡萄糖的肾脏提取率。

Renal extraction ratios for 51Cr-EDTA, PAH, and glucose in early insulin-dependent diabetic patients.

作者信息

Nyberg G, Granerus G, Aurell M

出版信息

Kidney Int. 1982 May;21(5):706-8. doi: 10.1038/ki.1982.85.

DOI:10.1038/ki.1982.85

Abstract

Renal clearances and extraction ratios for 51Cr-EDTA and PAH were studied in six young patients with insulin-dependent diabetes. The duration of the disease was 1 to 4 years, and no patient had signs of diabetic complications. Catheterization of the right renal vein and the left brachial artery was performed. The extraction ratios for 51Cr-EDTA, PAH, and glucose were determined at two different levels of blood glucose. Clearance for 51Cr-EDTA was increased by 9.7% and for PAH by 8.5% compared to normal control subjects while the extraction ratios for 51Cr-EDTA and PAH were normal. Extraction ratio for glucose was very low. There was no correlation between the individual HbA1 values and the clearances for 51Cr-EDTA and PAH. Extraction ratios for these substances were not influenced by acute changes in blood glucose level. The normal PAH extraction ratio indicates that PAH clearance is a reliable estimate of RPF in early insulin-dependent diabetes.

摘要

对6例胰岛素依赖型糖尿病年轻患者进行了51Cr-乙二胺四乙酸（51Cr-EDTA）和对氨基马尿酸（PAH）的肾清除率及提取率研究。病程为1至4年，且无患者有糖尿病并发症迹象。进行了右肾静脉和左肱动脉插管。在两个不同血糖水平测定了51Cr-EDTA、PAH和葡萄糖的提取率。与正常对照受试者相比，51Cr-EDTA清除率增加了9.7%，PAH清除率增加了8.5%，而51Cr-EDTA和PAH的提取率正常。葡萄糖提取率非常低。个体糖化血红蛋白（HbA1）值与51Cr-EDTA和PAH清除率之间无相关性。这些物质的提取率不受血糖水平急性变化的影响。正常的PAH提取率表明，在早期胰岛素依赖型糖尿病中，PAH清除率是肾血浆流量（RPF）的可靠估计值。