Annesley T M, Burritt M F, Kyle R A
Mayo Clin Proc. 1982 Sep;57(9):572-5.
A calcium-binding IgG K monoclonal protein in a patient with multiple myeloma and asymptomatic hypercalcemia was recognized, isolated, and characterized. In addition to binding by the whole IgG molecules, calcium was bound by purified Fab fragments and recombined heavy and light chains. In a competitive binding study, the isolated myeloma protein did not bind magnesium. Recognition of calcium-binding myeloma proteins is important in order to avoid therapy for hypercalcemia.
在一名患有多发性骨髓瘤和无症状高钙血症的患者中，识别、分离并鉴定出一种结合钙的IgG κ单克隆蛋白。除了与完整的IgG分子结合外，钙还能与纯化的Fab片段以及重组的重链和轻链结合。在一项竞争性结合研究中，分离出的骨髓瘤蛋白不结合镁。识别结合钙的骨髓瘤蛋白对于避免高钙血症的治疗很重要。
