Rubinstein E, Dreznik Z, Mark Z
Surg Gynecol Obstet. 1982 Sep;155(3):363-8.
The pharmacokinetics and therapeutic efficacy of gentamicin and cefsulodin were studied in an abscess model in the rat induced by Pseudomonas aeruginosa and a foreign body. Both agents reached therapeutic concentrations in the abscess fluid and its ultrafiltrate and persisted longer in the abscess fluid than in blood. Gentamicin did not prevent the development of abscesses or reduce the bacterial inoculum when administered immediately following the induction of the abscesses. Cefsulodin sterilized 82.7 per cent of abscesses in 61.5 per cent of injected rats. Low oxygen tension present in the abscess was probably responsible for the inefficacy of gentamicin in this model, while not significantly diminishing the antibacterial activity of cefsulodin.
在由铜绿假单胞菌和异物诱导的大鼠脓肿模型中，研究了庆大霉素和头孢磺啶的药代动力学及治疗效果。两种药物在脓肿液及其超滤液中均达到治疗浓度，且在脓肿液中持续的时间比在血液中更长。在脓肿形成后立即给药时，庆大霉素不能预防脓肿的形成，也不能减少细菌接种量。头孢磺啶使61.5%的注射大鼠中的82.7%的脓肿无菌化。脓肿中存在的低氧张力可能是庆大霉素在该模型中无效的原因，而对头孢磺啶的抗菌活性没有显著影响。
