Rubinstein E, Pritsch M, Mark Z, Spicehandler J
Eur J Clin Microbiol. 1982 Oct;1(5):272-7. doi: 10.1007/BF02019970.
The therapeutic efficacy of ceftriaxone and gentamicin was investigated in a foreign body induced abscess model in the rat by implanting a dialysis tube contaminated with Klebsiella pneumoniae into the subcutaneous tissue. Animals were treated for four days with ceftriaxone, gentamicin, and their combination starting immediately following or 48 h after the implantation. Peak free ceftriaxone and gentamicin abscess fluid levels were 4.3 and 2.6 mcg/ml, which were 7.3% and 37.5% of peak blood levels respectively. Both agents persisted longer in abscess fluid than in blood. Ceftriaxone inhibited the development of abscess formation when administered shortly after the implantation of the contaminated foreign body whereas gentamicin alone was without beneficial effect. When administered after 48 h ceftriaxone was less effective than immediately after implantation and gentamicin was again without any therapeutic effect. The effect of the combination of ceftriaxone and gentamicin was slightly better than ceftriaxone alone. Low oxygen tension may be an explanation for the lack of bactericidal effect of gentamicin. Ceftriaxone may be more suitable for the therapy of closed space infections caused by susceptible microorganisms than gentamicin.
通过将被肺炎克雷伯菌污染的透析管植入大鼠皮下组织，在大鼠异物诱导的脓肿模型中研究了头孢曲松和庆大霉素的治疗效果。在植入后立即或植入后48小时开始，用头孢曲松、庆大霉素及其组合对动物进行为期四天的治疗。头孢曲松和庆大霉素在脓肿液中的游离峰值水平分别为4.3和2.6 mcg/ml，分别为血药峰值水平的7.3%和37.5%。两种药物在脓肿液中的持续时间均长于血液。在植入受污染异物后不久给予头孢曲松可抑制脓肿形成的发展，而单独使用庆大霉素则无有益效果。在植入后48小时给予头孢曲松的效果不如植入后立即给药，庆大霉素再次没有任何治疗效果。头孢曲松和庆大霉素联合使用的效果略优于单独使用头孢曲松。低氧张力可能是庆大霉素缺乏杀菌作用的一个解释。与庆大霉素相比，头孢曲松可能更适合治疗由易感微生物引起的确闭腔感染。
