Henrard L, Pierard L, Limet R
Arch Mal Coeur Vaiss. 1982 Nov;75(11):1317-20.
Two cases of Prinzmetal angina with normal coronary arteries are reported: coronary spasm was demonstrated in the left anterior descending artery in the first, and in the right coronary artery in the second case. Invalidating angina persisted despite maximal medical treatment with nitrite derivatives, nifedipine, verapamil and amiodarone. Homolateral thoracic sympathectomy led to long term remission of symptoms in one case and a short remission in the other, who then had to undergo complete denervation by plexectomy. Two hours after reoperation a refractory spasm of the right coronary artery led to the death of the patient. The possible causes of refractory coronary spasm and possible therapeutic approaches are discussed with reference to these cases.
第一例患者,左前降支出现冠状动脉痉挛;第二例患者,右冠状动脉出现冠状动脉痉挛。尽管使用亚硝酸盐衍生物、硝苯地平、维拉帕米和胺碘酮进行了最大程度的药物治疗,但心绞痛仍未缓解。一例患者接受同侧胸交感神经切除术,症状得到长期缓解;另一例患者症状短期缓解,随后不得不接受神经丛切除术进行完全去神经支配。再次手术后两小时,右冠状动脉难治性痉挛导致患者死亡。结合这些病例讨论了难治性冠状动脉痉挛的可能原因及可能的治疗方法。