De Remigis P, Damiani A, Vianale L, D'Angelo M, Bonaduce S, Della Loggia F, Basilico L, Sensi S
Boll Soc Ital Biol Sper. 1982 Jun 15;58(11):663-5.
TRH-test is an usefull tool for diagnostic purpose in thyroid disease. We challenged with TRH 4 groups of patients (1 degrees non toxic diffuse goitre, 2 degrees nodular goitre (Plummer's disease), 3 degrees euthyroid ophthalmic Graves' disease, 4 degrees hemithyroidectomy) with different thyroid affections who showed no symptoms and presented normal values of total thyroid hormones, in comparison with a control group. These groups displayed normal and pathological (blunted or absent and exaggerated) responses of TSH to TRH. Therefore TRH-test ra presents a good mean to recognize subclinical forms both hyperthyroidism and hypothyroidism.
促甲状腺激素释放激素（TRH）试验是甲状腺疾病诊断中的一种有用工具。我们对4组患有不同甲状腺疾病但无症状且总甲状腺激素值正常的患者（1度非毒性弥漫性甲状腺肿、2度结节性甲状腺肿（普卢默病）、3度甲状腺功能正常的突眼性格雷夫斯病、4度甲状腺半切除术）进行了TRH激发试验，并与一个对照组进行比较。这些组显示促甲状腺激素（TSH）对TRH的正常和病理性（减弱或无反应以及过度反应）反应。因此，TRH试验是识别亚临床甲亢和甲减的良好手段。
