Preston R J
Cytogenet Cell Genet. 1982;33(1-2):20-6. doi: 10.1159/000131721.
If cells exposed to X-rays or chemical agents are incubated with inhibitors of DNA repair (cytosine arabinoside or aphidicolin), it is possible to accumulate single-strand gaps in the DNA at repairing regions. Upon reversal of the inhibition, these gaps can interact to form chromosome aberrations. It appears that the aberration frequency observed following treatment with radiation or chemical agents is greatly influenced by the rate repair of damage that is converted into aberrations. This argument also extends to considerations of the different cell-cycle-stage sensitivities, the relative sensitivities of different species, and the probability of observing interactive effects between two agents. These aspects are discussed in terms of their contribution to the interpretation of the mechanisms induction of chromosome aberrations.
如果将暴露于X射线或化学试剂的细胞与DNA修复抑制剂（阿糖胞苷或阿非迪霉素）一起培养，就有可能在修复区域的DNA中积累单链缺口。抑制作用解除后，这些缺口可相互作用形成染色体畸变。似乎用辐射或化学试剂处理后观察到的畸变频率受转化为畸变的损伤修复速率的极大影响。这一观点也延伸到对不同细胞周期阶段敏感性、不同物种的相对敏感性以及观察两种试剂之间相互作用效应的可能性的考虑。将根据它们对染色体畸变诱导机制解释的贡献来讨论这些方面。
