Muechler E K, Huang K E
Fertil Steril. 1982 Oct;38(4):423-6. doi: 10.1016/s0015-0282(16)46575-1.
A 24-year-old woman is described with irregular menstruation, anovulation, and infertility due to primary hypothyroidism and Hashimoto's thyroiditis. Her baseline gonadotropins and thyroid-stimulating hormone (TSH) were increased. Microsomal and thyroglobulin antibodies were present. Stimulation of pituitary hormone release with thyrotropin-releasing hormone (TRH) resulted in appropriate responses of TSH and prolactin (PRL) as well as a substantial rise in the level of luteinizing hormone (LH). Luteinizing hormone releasing factor (LRF) markedly inhibited LH release. Bromoergocryptine led to inhibition of TSH and PRL. These results suggest that specific and nonspecific responses of pituitary glycoproteins to provocative stimuli reflect a profound disturbance of the hypothalamic-pituitary axis in this case of hypothyroidism.
一名24岁女性因原发性甲状腺功能减退和桥本甲状腺炎出现月经不规律、无排卵及不孕。其基础促性腺激素和促甲状腺激素（TSH）升高。存在微粒体抗体和甲状腺球蛋白抗体。用促甲状腺激素释放激素（TRH）刺激垂体激素释放，导致TSH和催乳素（PRL）出现适当反应，同时促黄体生成素（LH）水平大幅升高。促黄体生成素释放因子（LRF）显著抑制LH释放。溴隐亭导致TSH和PRL受到抑制。这些结果表明，在该甲状腺功能减退病例中，垂体糖蛋白对刺激物的特异性和非特异性反应反映了下丘脑 - 垂体轴的严重紊乱。
