Braun-Falco O, Luderschmidt C, Maciejewski W, Scherer R
Hautarzt. 1978 Jul;29(7):371-7.
After an acute course of pharyngitis and bronchitis treated with Bactrim (trimethoprim and sulfamethoxazol), a 52 year old woman suddenly developed a widespread, sterile pustular eruption with predilection of the distal parts of the extremities. The histological and electron microscopical examinations showed intraepidermal pustules with underlying distinct leukocytoclastic vasculitis. Direct immunofluorescence revealed the prescence of intra- and perivascular deposits of C3 in the upper part of the dermis. Drug- and/or infection allergy is suggested to be responsible for the etiopathogenetic mechanism of leukocytoclastic vasculitis.
一名52岁女性在接受复方新诺明（甲氧苄啶和磺胺甲恶唑）治疗急性咽炎和支气管炎后，突然出现广泛的无菌性脓疱疹，好发于四肢远端。组织学和电子显微镜检查显示表皮内脓疱，其下有明显的白细胞破碎性血管炎。直接免疫荧光显示真皮上部血管内和血管周围有C3沉积。药物和/或感染过敏被认为是白细胞破碎性血管炎发病机制的原因。
