1例经意外口服激发试验确诊的羟氯喹引起的急性泛发性脓疱性皮疹病
A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation.
作者信息
Park Jae-Jeong, Yun Sook Jung, Lee Jee-Bum, Kim Seong-Jin, Won Young Ho, Lee Seung-Chul
机构信息
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
出版信息
Ann Dermatol. 2010 Feb;22(1):102-5. doi: 10.5021/ad.2010.22.1.102. Epub 2010 Feb 28.
Abstract
Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.
摘要
急性泛发性脓疱病（AGEP）是一种主要由药物引起的临床反应模式，其特征为在水肿性红斑背景上出现急性、非毛囊性无菌脓疱。羟氯喹（HCQ）已被广泛用于治疗风湿性和皮肤病，据报道HCQ是AGEP的罕见病因。一名患有皮肌炎和多关节痛1年病史的38岁女性，因对先前药物治疗无反应而接受HCQ治疗。开始HCQ治疗三周后，出现脓疱性皮肤病变，在停用HCQ并开始使用类固醇治疗后病变消退。在意外再次使用HCQ后，出现了类似的脓疱性皮疹。
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