1例经意外口服激发试验确诊的羟氯喹引起的急性泛发性脓疱性皮疹病
A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation.
作者信息
Park Jae-Jeong, Yun Sook Jung, Lee Jee-Bum, Kim Seong-Jin, Won Young Ho, Lee Seung-Chul
机构信息
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
出版信息
Ann Dermatol. 2010 Feb;22(1):102-5. doi: 10.5021/ad.2010.22.1.102. Epub 2010 Feb 28.
Abstract
Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.
摘要
急性泛发性脓疱病（AGEP）是一种主要由药物引起的临床反应模式，其特征为在水肿性红斑背景上出现急性、非毛囊性无菌脓疱。羟氯喹（HCQ）已被广泛用于治疗风湿性和皮肤病，据报道HCQ是AGEP的罕见病因。一名患有皮肌炎和多关节痛1年病史的38岁女性，因对先前药物治疗无反应而接受HCQ治疗。开始HCQ治疗三周后，出现脓疱性皮肤病变，在停用HCQ并开始使用类固醇治疗后病变消退。在意外再次使用HCQ后，出现了类似的脓疱性皮疹。
相似文献
1
A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation.1例经意外口服激发试验确诊的羟氯喹引起的急性泛发性脓疱性皮疹病
Ann Dermatol. 2010 Feb;22(1):102-5. doi: 10.5021/ad.2010.22.1.102. Epub 2010 Feb 28.
2
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature.羟氯喹诱导的急性泛发性脓疱性皮病：三例报告并文献复习
Clin Ther. 2008 May;30(5):930-40. doi: 10.1016/j.clinthera.2008.05.014.
3
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: first case report in Canada and review of the literature.羟氯喹诱发的急性泛发性发疹性脓疱病：加拿大首例病例报告及文献复习。
J Cutan Med Surg. 2013 Nov-Dec;17(6):414-8. doi: 10.2310/7750.2013.12105.
4
The First Pediatric Case of Acute Generalized Exanthematous Pustulosis Caused by Hydroxychloroquine.羟氯喹致急性泛发性发疹性脓疱病的首例儿科病例报告。
Pharmacology. 2019;104(1-2):57-59. doi: 10.1159/000500406. Epub 2019 May 8.
5
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation.羟氯喹诱导的急性泛发性脓疱性皮病：1例非典型临床表现病例
An Bras Dermatol. 2017 May-Jun;92(3):404-406. doi: 10.1590/abd1806-4841.20175561.
6
7
Initiation of hydroxychloroquine therapy during pregnancy can cause adverse effects and alter pregnancy outcomes: A case of acute generalised exanthematous pustulosis induced by hydroxychloroquine in a patient with systemic lupus erythematosus.羟氯喹治疗的启动可能会在妊娠期导致不良影响并改变妊娠结局：系统性红斑狼疮患者因羟氯喹致急性泛发性发疹性脓疱病 1 例。
Mod Rheumatol Case Rep. 2023 Jun 19;7(2):373-377. doi: 10.1093/mrcr/rxac089.
8
Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report.羟氯喹引发急性泛发性脓疱性皮病与史蒂文斯-约翰逊综合征重叠：一例报告
J Med Case Rep. 2020 Nov 3;14(1):210. doi: 10.1186/s13256-020-02504-8.
9
The necessity of patch testing in determining the causative drug of AGEP.在确定 AGEP 的致病药物时，斑贴试验的必要性。
J Cosmet Dermatol. 2021 Jul;20(7):2156-2159. doi: 10.1111/jocd.13841. Epub 2020 Nov 25.
10
Clinical features of acute generalized exanthematous pustulosis caused by hydroxychloroquine in rheumatology patients and exploration of gene mutations.风湿科患者中由羟氯喹引起的急性泛发性脓疱性皮病的临床特征及基因突变探索
Front Med (Lausanne). 2023 Apr 6;10:1161837. doi: 10.3389/fmed.2023.1161837. eCollection 2023.
引用本文的文献
1
Clinical features of acute generalized exanthematous pustulosis caused by hydroxychloroquine in rheumatology patients and exploration of gene mutations.风湿科患者中由羟氯喹引起的急性泛发性脓疱性皮病的临床特征及基因突变探索
Front Med (Lausanne). 2023 Apr 6;10:1161837. doi: 10.3389/fmed.2023.1161837. eCollection 2023.
2
Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients.药物引发的急性泛发性脓疱性皮病（AGEP）及其临床研究：297例患者的文献病例系列
J Clin Med. 2022 Jan 13;11(2):397. doi: 10.3390/jcm11020397.
3
[Drug-induced toxidermia in a patient receiving hydroxychloroquine as systemic therapy for primary Gougerot-Sjögren syndrome: a case report].[一名接受羟氯喹作为原发性舍格伦综合征全身治疗的患者发生药物性中毒性皮炎：病例报告]
Pan Afr Med J. 2021 Mar 18;38:283. doi: 10.11604/pamj.2021.38.283.28478. eCollection 2021.
4
Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine.泛发性脓疱状图状红斑：一种与羟氯喹相关的新划定的严重皮肤药物反应。
Dermatol Ther. 2020 May;33(3):e13380. doi: 10.1111/dth.13380. Epub 2020 Apr 16.
5
A case of prolonged generalized exanthematous pustulosis caused by hydroxychloroquine-Literature review.一例由羟氯喹引起的迁延性泛发性脓疱性皮病——文献综述
Clin Case Rep. 2018 Oct 26;6(12):2391-2395. doi: 10.1002/ccr3.1811. eCollection 2018 Dec.
6
AGEP overlap induced by hydroxychloroquine: a case report and literature review.羟氯喹引发的中毒性表皮坏死松解症重叠综合征：一例报告及文献综述
J Community Hosp Intern Med Perspect. 2018 Dec 11;8(6):360-362. doi: 10.1080/20009666.2018.1547089. eCollection 2018.
7
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation.羟氯喹诱导的急性泛发性脓疱性皮病：1例非典型临床表现病例
An Bras Dermatol. 2017 May-Jun;92(3):404-406. doi: 10.1590/abd1806-4841.20175561.
8
Hydroxychloroquine-Induced Erythema Multiforme.羟氯喹诱导的多形红斑
J Clin Rheumatol. 2017 Mar;23(2):127-128. doi: 10.1097/RHU.0000000000000417.
9
Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing.羟氯喹诱导的急性泛发性脓疱性皮疹伴斑贴试验阳性
Indian J Pharmacol. 2015 Nov-Dec;47(6):693-4. doi: 10.4103/0253-7613.169589.
10
Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review.环孢素成功治疗羟氯喹诱导的顽固性急性泛发性脓疱性皮病：病例报告及文献综述
Ann Dermatol. 2015 Aug;27(4):431-4. doi: 10.5021/ad.2015.27.4.431. Epub 2015 Jul 29.
本文引用的文献
1
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature.羟氯喹诱导的急性泛发性脓疱性皮病：三例报告并文献复习
Clin Ther. 2008 May;30(5):930-40. doi: 10.1016/j.clinthera.2008.05.014.
2
A study of drug eruptions by provocative tests.通过激发试验对药疹的一项研究。
Indian J Dermatol Venereol Leprol. 2001 Sep-Oct;67(5):238-9.
3
Generalized pustules in a healthy woman.一名健康女性身上出现泛发性脓疱。
J Drugs Dermatol. 2002 Jul;1(1):63-5.
4
Acute generalized exanthematous pustulosis (AGEP)--a clinical reaction pattern.急性泛发性脓疱性皮病（AGEP）——一种临床反应模式。
J Cutan Pathol. 2001 Mar;28(3):113-9. doi: 10.1034/j.1600-0560.2001.028003113.x.
5
Acute generalized exanthematous pustulosis (AGEP): manifestation of drug allergy to propicillin.急性泛发性脓疱性皮病（AGEP）：对丙匹西林的药物过敏表现。
Contact Dermatitis. 1995 Sep;33(3):204-5. doi: 10.1111/j.1600-0536.1995.tb00553.x.
6
Pustular drug eruptions: a histopathological spectrum.脓疱性药疹：组织病理学谱
Histopathology. 1993 Jun;22(6):569-73. doi: 10.1111/j.1365-2559.1993.tb00178.x.
7
[Acute generalized exanthematic pustuloses (four cases) (author's transl)].急性泛发性脓疱性皮病（4例）（作者译）
Ann Dermatol Venereol. 1980 Jan-Feb;107(1-2):37-48.
8
Pharmacologic actions of 4-aminoquinoline compounds.4-氨基喹啉化合物的药理作用。
Am J Med. 1983 Jul 18;75(1A):5-10. doi: 10.1016/0002-9343(83)91264-0.
9
Generalized pustular psoriasis. A clinical and epidemiological study of 104 cases.泛发性脓疱型银屑病。104例临床与流行病学研究。
Br J Dermatol. 1968 Dec;80(12):771-93. doi: 10.1111/j.1365-2133.1968.tb11947.x.
10
[Generalized acute pustulosis. An unusual presentation of leukocytoclastic vasculitis].[泛发性急性脓疱病。白细胞破碎性血管炎的一种不寻常表现]
Hautarzt. 1978 Jul;29(7):371-7.
Zotero 插件