Marmion B P, Burrell C J, Tonkin R W, Dickson J
Rev Infect Dis. 1982 May-Jun;4(3):619-37. doi: 10.1093/clinids/4.3.619.
In 1969-1970 there was a sharp outbreak of hepatitis associated with hemodialysis in two Edinburgh hospitals; mortality was 24% among renal patients and 31% in staff members. The epidemiology of the outbreak, the measures taken to control it, and the efforts made to exclude hepatitis B virus infections during an eight-year period after the outbreak, were reviewed in the light of a retesting of stored specimens by modern diagnostic techniques for hepatitis A and B viruses. This review reveals that the outbreak involved some dual infections with both hepatitis B and non-A, non-B hepatitis viruses and that the occurrence of two infections at once was probably related to the exceptional virulence of the outbreak. The review also reaffirms that the routine serotesting of renal patients and staff members and the dialysis of infected patients in a geographically separate isolation facility are effective methods of controlling the spread of hepatitis B virus in hemodialysis units.
1969年至1970年期间，爱丁堡的两家医院爆发了一起与血液透析相关的严重肝炎疫情；肾病患者的死亡率为24%，工作人员的死亡率为31%。根据对储存标本采用现代甲型和乙型肝炎病毒诊断技术进行重新检测的结果，对此次疫情的流行病学、为控制疫情所采取的措施以及疫情爆发后八年间为排除乙型肝炎病毒感染所做的努力进行了回顾。此次回顾发现，疫情涉及一些同时感染乙型肝炎病毒和非甲非乙型肝炎病毒的双重感染病例，且两种感染同时发生可能与疫情的异常高致病性有关。该回顾还重申，对肾病患者和工作人员进行常规血清检测，以及在地理上独立的隔离设施中对感染患者进行透析，是控制血液透析单位乙型肝炎病毒传播的有效方法。
