Sherwin I, Peron-Magnan P, Bancaud J, Bonis A, Talairach J
Arch Neurol. 1982 Oct;39(10):621-5. doi: 10.1001/archneur.1982.00510220019004.
Retrospective analysis of the psychiatric diagnoses in a group of patients surgically relieved of medically intractable epilepsy tested the hypothesis that patients with left-sided temporal lobe epileptogenic lesions are at greater risk for the development of a so-called schizophrenic-like psychosis than are those with right-sided temporal lobe epileptogenic lesions. The data confirmed the hypothesis and also demonstrated an increased prevalence of sinistrals in the psychotic group. Thus, epilepsy involving the dominant hemisphere at the inception of the seizure disorder is the significant risk factors. The data also indicated that a psychosis is unlikely to develop in patients with other (nontemporal) forms of focal epilepsy. On the basis of these data and data from other studies, the prevalence of psychosis in patients with poorly controlled temporal lobe epilepsy was estimated to be approximately 10% to 15%.
对一组通过手术缓解药物难治性癫痫的患者进行精神病学诊断的回顾性分析，检验了以下假设：左侧颞叶致痫性病变的患者比右侧颞叶致痫性病变的患者发生所谓精神分裂症样精神病的风险更高。数据证实了这一假设，并且还表明精神病组中左利手者的患病率有所增加。因此，在癫痫发作障碍开始时累及优势半球的癫痫是重要的危险因素。数据还表明，其他（非颞叶）局灶性癫痫患者不太可能发生精神病。根据这些数据以及其他研究的数据，估计颞叶癫痫控制不佳的患者中精神病的患病率约为10%至15%。
