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[γ-氨基丁酸(GABA)在中脑中央灰质水平对飞行反应形成的影响]

[Implication of gamma-aminobutyric acid (GABA) at the mesencephalic central gray level, in the elaboration of flight responses].

作者信息

Di Scala G, Schmitt P, Karli P

出版信息

C R Seances Acad Sci III. 1982 Apr 19;294(14):715-8.

PMID:6812873
Abstract

In the rat, a microinjection of bicuculline methiodide (0.03 to 0.065 nmole) into the mesencephalic central gray (GC) provokes a flight response. At a lower dose, it reduces - or increases - the latency with which the rat switches off an electrical stimulation applied to the GC. This latency is regularly increased by a local microinjection of muscimol. These results suggest that a GABAergic link within the GC is involved in the generation of an aversive effect and of the flight response which may express it.

摘要

在大鼠中,向中脑中央灰质(GC)微量注射甲硫酸荷包牡丹碱(0.03至0.065纳摩尔)会引发逃避反应。在较低剂量下,它会缩短或延长大鼠停止施加于GC的电刺激的潜伏期。局部微量注射蝇蕈醇会使该潜伏期有规律地延长。这些结果表明,GC内的γ-氨基丁酸能联系参与了厌恶效应的产生以及可能表达该效应的逃避反应。

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