Di Scala G, Schmitt P, Karli P
Brain Res. 1984 Sep 10;309(2):199-208.
Microinjections of different doses of bicuculline methiodide (BM) were performed into the mesencephalic central gray (CG), the medial hypothalamus (MH) and lateral hypothalamus (LH). Flight reactions could be induced by microinjections of BM into either the CG or the MH. However, the type of flight behavior was different whether the injection was made in the CG or the MH. Furthermore, microinjections of 35 ng of BM in either structure produced an increase in locomotor activity whose time course differed according to the injected structure, and an increase in rearings was induced at MH but not at CG sites. At lateral hypothalamic sites, BM produced an increase in locomotor activity and rearings but no jump. These effects were antagonized in a dose-dependent manner by a local pretreatment with 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), a GABA agonist. These results suggest that (1) at the level of both the MH and the CG, a GABAergic link is involved in the inhibition of a substrate whose activation produces aversive effects, and (2) the aversive effect induced by CG BM microinjection seems to be different from that induced by MH BM microinjection.
将不同剂量的甲硫酸荷包牡丹碱（BM）微量注射到中脑中央灰质（CG）、内侧下丘脑（MH）和外侧下丘脑（LH）。向CG或MH中微量注射BM均可诱发逃避反应。然而，根据注射部位是CG还是MH，逃避行为的类型有所不同。此外，在任一结构中微量注射35 ng的BM都会使运动活性增加，其时间进程因注射结构而异，并且在MH部位而非CG部位会诱发竖毛行为增加。在外侧下丘脑部位，BM会使运动活性和竖毛行为增加，但不会引发跳跃。局部预先用γ-氨基丁酸（GABA）激动剂4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇（THIP）处理后，这些效应会以剂量依赖的方式受到拮抗。这些结果表明：（1）在MH和CG水平，GABA能联系均参与对一种激活后会产生厌恶效应的底物的抑制；（2）CG微量注射BM所诱发的厌恶效应似乎与MH微量注射BM所诱发的厌恶效应不同。
