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糖尿病中的锂:一种矛盾的反应。

Lithium in diabetes mellitus: a paradoxical response.

作者信息

Waziri R, Nelson J

出版信息

J Clin Psychiatry. 1978 Jul;39(7):623-5.

PMID:681292
Abstract

An unusual hyperglycemic effect of lithium was observed in a patient suffering from diabetes mellitus and mania. In the presence of constant insulin dosage, high serum lithium levels were correlated with high fasting bloos sugar, while lowering of the lithium level led to a lowering the fasting blood sugar. These observations are discussed in terms of the effects of lithium on glucose metabolism and with particular emphasis on the ability of lithium to increase the release of glucagon.

摘要

在一名患有糖尿病和躁狂症的患者中观察到锂具有异常的高血糖效应。在胰岛素剂量恒定的情况下,高血清锂水平与高空腹血糖相关,而锂水平降低则导致空腹血糖降低。本文根据锂对葡萄糖代谢的影响进行了讨论,尤其强调了锂增加胰高血糖素释放的能力。

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