Greenblatt D J, Gross P L, Harris J, Shader R I, Ciraulo D A
J Clin Psychiatry. 1978 Aug;39(8):673-5.
A 30 year old male, with a history of methalqualone and barbiturate abuse, developed a delirium tremens-like syndrome following discontinuation of the medications. Shortly following high doses of parenteral haloperidol administered for treatment of the withdrawal syndrome, the patient developed severe hyperthermia, with body temperatures reaching as high as 108 degrees F. The hyperthermic episode was followed by cardiovascular collapse, multiple complications, and death. The sequence of events strongly suggests that haloperidol therapy was casually related to the development of fatal hyperthermia. Thus the butyrophenone haloperidol, like the phenothiazine derivatives, can produce clinically important impairment of thermoregulation.
一名30岁男性，有甲喹酮和巴比妥类药物滥用史，在停药后出现了震颤谵妄样综合征。在给予大剂量胃肠外氟哌啶醇治疗戒断综合征后不久，患者出现严重高热，体温高达108华氏度。高热发作后出现心血管衰竭、多种并发症并死亡。这一系列事件强烈表明氟哌啶醇治疗与致命性高热的发生存在因果关系。因此，丁酰苯类药物氟哌啶醇与吩噻嗪衍生物一样，可引起临床上重要的体温调节障碍。
