Cantelmi A, Gaiti A, Porcellati G, Ansidei V, Binazzi M
Farmaco Sci. 1982 Sep;37(9):612-7.
The activity of phospholipase A2 was tested both in rat skin and human psoriatic skin before and after systemic treatment with a retinoic acid derivative: RO 10-9359. An increase of activity was found in the rat skin homogenates when the animals were treated with 3 mg/kg/day of the drug for 8 days, while no effect was found following treatment with 1.5 mg/kg/day for 10 days. On the contrary a decrease of this activity was found in homogenates from both involved and uninvolved skin of psoriatic patients after systemic treatment with 1-1.5 mg/kg/day for 10 days. These different results are discussed also in the light of the clinical effect of RO 10-9359 on psoriasis.
在用维甲酸衍生物RO 10 - 9359进行全身治疗前后，对大鼠皮肤和人银屑病皮肤中的磷脂酶A2活性进行了检测。当以3毫克/千克/天的剂量给动物用药8天时，在大鼠皮肤匀浆中发现活性增加，而以1.5毫克/千克/天的剂量用药10天则未发现效果。相反，银屑病患者在以1 - 1.5毫克/千克/天的剂量进行全身治疗10天后，其患部和未患部皮肤的匀浆中该活性均降低。还根据RO 10 - 9359对银屑病的临床疗效对这些不同结果进行了讨论。
