依曲替酯对银屑病皮肤中花生四烯酸代谢的环氧化酶和脂氧化酶产物的影响。
The effect of etretinate on the cyclo-oxygenase and lipoxygenase products of arachidonic acid metabolism in psoriatic skin.
作者信息
Wong E, Barr R M, Brain S D, Greaves M W, Olins L A, Mallet A I
出版信息
Br J Clin Pharmacol. 1984 Oct;18(4):523-7. doi: 10.1111/j.1365-2125.1984.tb02499.x.
Eight psoriatic patients were treated with etretinate (50 mg daily) for 6 weeks. Skin chamber exudates from involved and uninvolved skin were assayed for arachidonic acid, 12-HETE, PGE2 and for neutrophil chemokinetic activity co-chromatographing with leukotriene B4, before and at weekly intervals during therapy. Pre-treatment concentrations of arachidonic acid, 12-HETE and leukotriene B4-like chemokinetic activity but not of PGE2 were elevated in involved skin when compared to uninvolved skin. The concentrations of arachidonic acid and 12-HETE declined during therapy but changes in PGE2 were minimal. LTB4-like activity was detectable in involved skin both before and after etretinate treatment. Clinically, scaling and infiltration improved but erythema was still evident.
8例银屑病患者接受依曲替酯（每日50毫克）治疗6周。在治疗前及治疗期间每周一次，对受累皮肤和未受累皮肤的皮肤腔渗出物进行花生四烯酸、12-羟基二十碳四烯酸（12-HETE）、前列腺素E2（PGE2）检测，并与白三烯B4进行共色谱分析以检测中性粒细胞趋化活性。与未受累皮肤相比，受累皮肤中花生四烯酸、12-HETE和白三烯B4样趋化活性的预处理浓度升高，但PGE2浓度未升高。治疗期间花生四烯酸和12-HETE的浓度下降，但PGE2的变化最小。在依曲替酯治疗前后，受累皮肤中均可检测到白三烯B4样活性。临床上，鳞屑和浸润有所改善，但红斑仍很明显。
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