Barraclough D, Brook A, Brooks P, Boyden K, Thomas D, Tymms K
J Rheumatol Suppl. 1982 Jul-Aug;8:197-200.
We compared auranofin (AF) in a single blind multi-centre study with gold sodium thiomalate and D-penicillamine in the treatment of rheumatoid arthritis. Adult patients with disease duration 6-60 months without previous treatment with gold salts with persistent active disease, were included. Thirty-nine patients, 13 in each treatment group, have so far been entered. Cumulative toxicity data and some results of efficacy assessments in those completing 9 months of treatment are presented. AF is very well tolerated, judgment concerning efficacy must await the end of the trial.
我们在一项单盲多中心研究中，将金诺芬（AF）与硫代苹果酸金钠和青霉胺用于类风湿关节炎的治疗进行了比较。纳入了病程为6 - 60个月、既往未接受金盐治疗且疾病持续活动的成年患者。目前已有39名患者入组，每个治疗组13名。本文呈现了累积毒性数据以及完成9个月治疗患者的一些疗效评估结果。金诺芬耐受性良好，关于疗效的判断尚需等待试验结束。
