David-Chaussé J
Nouv Presse Med. 1982 Aug 28;11(33):2522-4.
During a non-comparative multicentric study, 70 patients suffering from various rheumatological diseases were treated by pirprofen for an average duration of 32 weeks (from 1 to 121 weeks). The daily dose varied from 400 to 1200 mg. Efficacy was judged good or excellent in 53 of the 70 patients (75%). Side effects, especially digestive, were noted in 27 patients (38%). They only caused discontinuation of treatment in 9 patients (13%). Amongst the 38 side effects, 26 occurred during the first 8 weeks of treatment. Despite the long duration of the treatment, the overall tolerance of pirprofen was good or acceptable in 87,5% of patients. The very high level of compliance in this long-term treatment attests to the good tolerance of pirprofen.
在一项非对照多中心研究中，70例患有各种风湿性疾病的患者接受了吡洛芬治疗，平均疗程为32周（1至121周）。每日剂量为400至1200毫克。70例患者中有53例（75%）疗效判定为良好或极佳。27例患者（38%）出现副作用，尤其是消化系统副作用。只有9例患者（13%）因副作用停药。在38例副作用中，26例发生在治疗的前8周。尽管治疗时间长，但87.5%的患者对吡洛芬的总体耐受性良好或可接受。这种长期治疗中非常高的依从性证明了吡洛芬的良好耐受性。
