在斯普拉格-道利大鼠中特异性诱导红白血病和髓性白血病。

Huggins C B, Grand L, Ueda N

Proc Natl Acad Sci U S A. 1982 Sep;79(17):5411-4. doi: 10.1073/pnas.79.17.5411.

The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythro-leukemia in high incidence in the rats, whereas myelogenous leukemia was not produced.

在单一品系的大鼠中，研究了两种强效化学致癌物对两种白血病的实验诱导作用。在斯普拉格-道利大鼠中，一系列静脉注射N-亚硝基-N-甲基脲可选择性地高产量诱发髓性白血病，而不会诱发红白血病。相反，一组静脉注射7,8,12-三甲基苯并[a]蒽能在大鼠中特异性地高发病率诱发红白血病，而不会产生髓性白血病。