妊娠早期血清游离脂肪酸水平：乙酰水杨酸的影响

Serum levels of free fatty acids in the first trimester of pregnancy: effect of acetylsalicylic acid.

作者信息

Haataja M, Grönroos M, Honkonen E, Paul R, Nieminen A L, Anttila M

出版信息

Prostaglandins Leukot Med. 1982 Jul;9(1):61-9. doi: 10.1016/0262-1746(82)90073-7.

Abstract

The serum levels of free fatty acids were determined before and after an oral dose of 1000 mg acetylsalicylic acid (ASA) during the 7-11th weeks of pregnancy in 11 women admitted to hospital for legal abortion and in 8 women admitted for operative (hysterectomy) treatment because of fibroids. Thirteen healthy women of reproductive age served as controls. The levels of linoleic, alpha-linolenic, myristic, oleic, palmitic and palmitoleic acids were significantly lower in pregnant women than in the hysterectomy group. The level of arachidonic acid was higher in the pregnant and hysterectomy groups than in controls. Serum free fatty acids had a negative correlation with the duration of pregnancy. ASA treatment tended to increase the levels of many fatty acids in serum. Serum arachidonic acid levels after ASA treatment correlated significantly with the salicylate concentrations in myometrium and the levels of most other fatty acids with the salicylate concentration in endometrium.

摘要

对11名因合法堕胎入院的孕妇以及8名因子宫肌瘤接受手术（子宫切除术）治疗的妇女，在妊娠第7 - 11周口服1000毫克乙酰水杨酸（ASA）前后测定其血清游离脂肪酸水平。选取13名健康育龄妇女作为对照。孕妇体内亚油酸、α-亚麻酸、肉豆蔻酸、油酸、棕榈酸和棕榈油酸的水平显著低于子宫切除组。孕妇组和子宫切除组中花生四烯酸的水平高于对照组。血清游离脂肪酸与妊娠持续时间呈负相关。ASA治疗倾向于使血清中多种脂肪酸水平升高。ASA治疗后血清花生四烯酸水平与子宫肌层中水杨酸盐浓度显著相关，而大多数其他脂肪酸水平与子宫内膜中水杨酸盐浓度相关。