McElroy J F, Du Pont A F, Feldman R S
Psychopharmacology (Berl). 1982;77(4):356-9. doi: 10.1007/BF00432770.
This study tested a behavior-suppressing punishment system and how its activity may be altered by agents known to interrupt or enhance serotonergic (5-HT) transmission. Holtzman male albino rats were tested for shuttle box avoidance acquisition and intertrial responding either 1 or 8 h following daily injection of fenfluramine (FEN) or fluoxetine (FXT). When the drug-test interval was 1 h, a time when both drugs are presumably potentiating 5-HT activity, avoidance acquisition and intertrial responding were impaired. When testing occurred 8 h after drug treatment, a time when 5-HT level are unaltered by FXT and are maximally reduced by FEN, these drugs had no effect on avoidance acquisition, but FEN produced an increase in intertrial responses whereas FXT did not. These results support the proposal of an inhibitory 5-HT system. Furthermore, these data demonstrate that FEN is capable of exerting a biphasic action on intertrial responding and suggest that the time interval between drug administration and behavioral testing is a crucial variable when investigating FEN.
本研究测试了一种行为抑制性惩罚系统，以及已知可中断或增强5-羟色胺（5-HT）传递的药物对其活性的影响。对霍尔兹曼雄性白化大鼠进行穿梭箱回避学习和试验间期反应测试，每日注射芬氟拉明（FEN）或氟西汀（FXT）后1小时或8小时进行测试。当药物测试间隔为1小时，即两种药物可能都在增强5-HT活性时，回避学习和试验间期反应均受损。当在药物治疗后8小时进行测试时，此时FXT不改变5-HT水平，而FEN使其最大程度降低，这些药物对回避学习没有影响，但FEN使试验间期反应增加，而FXT则没有。这些结果支持了5-HT抑制系统的观点。此外，这些数据表明FEN对试验间期反应具有双相作用，并表明给药与行为测试之间的时间间隔是研究FEN时的一个关键变量。
