Joly D, Sanger D J
Pharmacol Biochem Behav. 1986 Feb;24(2):199-204. doi: 10.1016/0091-3057(86)90338-2.
Previous work has shown that subchronic administration of antidepressant drugs can reverse the behavioral and physiological changes produced by removal of the olfactory bulbs of rats. It has also been reported that acute administration of drugs believed to enhance serotonergic transmission can improve passive avoidance performance in bulbectomized rats. In order to follow up this observation the effects of the serotonin reuptake inhibitor, fluoxetine, were studied in bulbectomized and control rats. Fluoxetine produced a dose-related improvement in the passive avoidance behavior of bulbectomized rats in a step-down task and in a Y-maze. The effect of fluoxetine on step-down avoidance was blocked by metergoline and was also shown by zimeldine, another inhibitor of serotonin reuptake. However, in tests of active avoidance responding in a shuttle box and exploratory locomotion, fluoxetine produced similar disruptions of behavior in both bulbectomized and control animals. Thus, the effects of fluoxetine on the behavior of bulbectomized rats are dependent upon the behavioral test.
先前的研究表明，亚慢性给予抗抑郁药物可逆转大鼠嗅球切除所产生的行为和生理变化。也有报道称，急性给予被认为能增强5-羟色胺能传递的药物可改善嗅球切除大鼠的被动回避行为。为了跟进这一观察结果，研究了5-羟色胺再摄取抑制剂氟西汀对嗅球切除大鼠和对照大鼠的影响。氟西汀在一步下降任务和Y迷宫中使嗅球切除大鼠的被动回避行为产生剂量相关的改善。氟西汀对一步下降回避的作用被麦角林阻断，另一种5-羟色胺再摄取抑制剂齐美利定也显示出同样的作用。然而，在穿梭箱中的主动回避反应测试和探究性运动测试中，氟西汀在嗅球切除大鼠和对照动物中均产生了类似的行为干扰。因此，氟西汀对嗅球切除大鼠行为的影响取决于行为测试。
