一种人类白细胞抗原-DR抗原与甲状腺癌之间存在强关联。

Strong association between an HLA-DR antigen and thyroid carcinoma.

作者信息

Panza N, Del Vecchio L, Maio M, De Felice M, Lombardi G, Minozzi M, Zappacosta S

出版信息

Tissue Antigens. 1982 Aug;20(2):155-8. doi: 10.1111/j.1399-0039.1982.tb00340.x.

DOI:10.1111/j.1399-0039.1982.tb00340.x

Abstract

A group of 20 patients affected with thyroid carcinoma, all from Southern Italy, was typed for HLA-A, -B, -C and -DR antigens. Sixteen of them (80%) typed for DR1, while in the control group (120 unrelated healthy individuals from the same region) only 22 (18.3%) shared the same antigen (chi 2 = 32.96). The data indicate a highly significant association between the HLA-DR1 gene and the thyroid carcinoma.

摘要

一组20例甲状腺癌患者均来自意大利南部，对其进行了HLA - A、- B、- C和 - DR抗原分型。其中16例（80%）分型为DR1，而在对照组（来自同一地区的120名无血缘关系的健康个体）中，只有22例（18.3%）具有相同抗原（卡方 = 32.96）。数据表明HLA - DR1基因与甲状腺癌之间存在高度显著的关联。