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Metabolic activation of ftorafur [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway.

作者信息

El Sayed Y M, Sadée W

出版信息

Biochem Pharmacol. 1982 Sep 15;31(18):3006-8. doi: 10.1016/0006-2952(82)90279-9.

DOI:10.1016/0006-2952(82)90279-9
PMID:6814451
Abstract
摘要

相似文献

1
Metabolic activation of ftorafur [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway.
Biochem Pharmacol. 1982 Sep 15;31(18):3006-8. doi: 10.1016/0006-2952(82)90279-9.
2
Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes.R,S-1-(四氢-2-呋喃基)-5-氟尿嘧啶（替加氟）通过可溶性酶代谢活化为5-氟尿嘧啶。
Cancer Res. 1983 Sep;43(9):4039-44.
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Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil to 5-fluorouracil.
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Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone.
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Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil).呋喃氟尿嘧啶（R,S-1-(四氢-2-呋喃基)-5-氟尿嘧啶）的立体选择性代谢
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The pharmacology of ftorafur (R, S-1-(tetrahydro-2-furanyl)-5-fluorouracil.呋氟尿嘧啶（R，S-1-（四氢-2-呋喃基）-5-氟尿嘧啶）的药理学
Recent Results Cancer Res. 1981;76:100-14. doi: 10.1007/978-3-642-81565-2_9.
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Disposition and metabolism of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) in humans.
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Identification of metabolites of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT-207) formed in vitro by rat liver microsomes.
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Enzymatic formation of 5-fluorouracil from 1-(tetrahydro-2-furanyl)- 5-fluorouracil (tegafur) in human tumor tissues.人肿瘤组织中1-(四氢-2-呋喃基)-5-氟尿嘧啶（替加氟）酶促形成5-氟尿嘧啶。
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Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.在体外人肝微粒体中，替加氟向5-氟尿嘧啶的生物活化由细胞色素P-450 2A6催化。
Clin Cancer Res. 2000 Nov;6(11):4409-15.

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