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Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone.

作者信息

Au J L, Sadée W

出版信息

Cancer Res. 1980 Aug;40(8 Pt 1):2814-9.

PMID:6771006
Abstract
摘要

相似文献

1
Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone.
Cancer Res. 1980 Aug;40(8 Pt 1):2814-9.
2
Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes.R,S-1-(四氢-2-呋喃基)-5-氟尿嘧啶（替加氟）通过可溶性酶代谢活化为5-氟尿嘧啶。
Cancer Res. 1983 Sep;43(9):4039-44.
3
Metabolic activation of ftorafur [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway.
Biochem Pharmacol. 1982 Sep 15;31(18):3006-8. doi: 10.1016/0006-2952(82)90279-9.
4
Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil).呋喃氟尿嘧啶（R,S-1-(四氢-2-呋喃基)-5-氟尿嘧啶）的立体选择性代谢
Cancer Chemother Pharmacol. 1981;7(1):55-9. doi: 10.1007/BF00258214.
5
Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil to 5-fluorouracil.
Jpn J Pharmacol. 1984 Sep;36(1):43-9. doi: 10.1254/jjp.36.43.
6
Disposition and metabolism of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) in humans.
Cancer Res. 1978 Nov;38(11 Pt 1):3867-70.
7
Formation pathways of gamma-butyrolactone from the furan ring of tegafur during its conversion to 5-fluorouracil.在替加氟转化为 5-氟尿嘧啶的过程中，来自替加氟呋喃环的γ-丁内酯的形成途径。
Drug Metab Dispos. 2010 Aug;38(8):1267-76. doi: 10.1124/dmd.110.032797. Epub 2010 May 12.
8
Hydroxylated metabolies of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) in rats and rabbits.
Cancer Res. 1978 Jan;38(1):210-4.
9
Metabolism of 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil in mice.
J Natl Cancer Inst. 1979 Aug;63(2):465-8.
10
[Participation of non-specific rat liver microsome oxidases in destruction of Nl-furanidylpyrimidines].[非特异性大鼠肝微粒体氧化酶在N1-呋喃基嘧啶破坏中的作用]
Biull Eksp Biol Med. 1977 Feb;83(2):162-4.

引用本文的文献

1
UFT and its metabolite gamma-butyrolactone (GBL) inhibit angiogenesis induced by vascular endothelial growth factor in advanced cervical carcinoma.优福定及其代谢产物γ-丁内酯（GBL）可抑制晚期宫颈癌中血管内皮生长因子诱导的血管生成。
Med Oncol. 2008;25(2):214-21. doi: 10.1007/s12032-007-9023-1. Epub 2007 Oct 30.
2
Oral ftorafur plus intramuscular thiotepa as adjuvant chemotherapy in patients with breast cancer.口服替加氟加肌肉注射噻替派作为乳腺癌患者的辅助化疗
Med Oncol. 2002;19(4):227-32. doi: 10.1385/MO:19:4:227.
3
Tegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil.
替加氟/尿嘧啶联合亚叶酸钙治疗结直肠癌：氟尿嘧啶的双重调节作用
Drugs. 1999;58 Suppl 3:77-83. doi: 10.2165/00003495-199958003-00011.
4
Chronic active hepatitis and liver cirrhosis in association with combined tamoxifen/tegafur adjuvant therapy.他莫昔芬/替加氟联合辅助治疗相关的慢性活动性肝炎和肝硬化
Dig Dis Sci. 1995 Dec;40(12):2602-7. doi: 10.1007/BF02220448.
5
A case of allergic liver injury induced by tegafur.一例替加氟引起的过敏性肝损伤
J Gastroenterol. 1994 Feb;29(1):88-92. doi: 10.1007/BF01229081.
6
Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil).呋喃氟尿嘧啶（R,S-1-(四氢-2-呋喃基)-5-氟尿嘧啶）的立体选择性代谢
Cancer Chemother Pharmacol. 1981;7(1):55-9. doi: 10.1007/BF00258214.
7
Pharmacokinetics of ftorafur after intravenous and oral administration.
Cancer Chemother Pharmacol. 1983;10(3):150-3. doi: 10.1007/BF00255750.
8
Hepatic conversion of 1-(tetrahydro-2-furanyl)-5-fluorouracil into 5-fluorouracil in patients with hepatocellular carcinoma.
Gastroenterol Jpn. 1987 Feb;22(1):55-62. doi: 10.1007/BF02806335.
9
Antitumor activity of BOF-A2, a new 5-fluorouracil derivative.新型5-氟尿嘧啶衍生物BOF-A2的抗肿瘤活性
Jpn J Cancer Res. 1989 Feb;80(2):173-81. doi: 10.1111/j.1349-7006.1989.tb02286.x.
10
Oral tegafur in the treatment of gastrointestinal tract cancers: a phase II study.口服替加氟治疗胃肠道癌症：一项II期研究。
Br J Cancer. 1990 Mar;61(3):475-8. doi: 10.1038/bjc.1990.105.