Echols H
Biochimie. 1982 Aug-Sep;64(8-9):571-5. doi: 10.1016/s0300-9084(82)80089-8.
This article discusses ideas about the ways in which the high fidelity of DNA replication is achieved: base selection, exonucleolytic editing, and postreplicative proofreading. I also review possible mechanisms for the enhanced mutation rate associated with SOS induction. The concept of environmental control of mutation rate and other modes of genetic variation is also considered from the point of view that SOS induction is an example of "genetic revolution".
本文讨论了实现DNA复制高保真度的方式的相关观点：碱基选择、核酸外切酶编辑和复制后校对。我还回顾了与SOS诱导相关的突变率增加的可能机制。从SOS诱导是“遗传革命”的一个例子这一观点出发，也考虑了突变率的环境控制概念和其他遗传变异模式。
