Tiedemann J, Chessells J M, Sandland R M
Br Med J (Clin Res Ed). 1982 Dec 4;285(6355):1614-6. doi: 10.1136/bmj.285.6355.1614.
In 22 boys among a group of 169 with acute lymphoblastic leukaemia the first relapse occurred in the testis. In 14 of these late isolated testicular relapse was detected on routine biopsy or became apparent after treatment was electively stopped. Eleven of these boys were treated with reinduction, irradiation of 2400 rads to both testicles, intrathecal methotrexate, and two years of chemotherapy; 10 remained well and were in second complete remission from two and a half to five and a half years later. It is concluded that boys with late isolated testicular relapse fare better than those with late marrow relapse and may have a change of long-term disease-free survival.
在169例急性淋巴细胞白血病患者中，有22例男孩首次复发发生在睾丸。其中14例在常规活检时发现晚期孤立性睾丸复发，或在选择性停止治疗后复发明显。这些男孩中有11例接受了再诱导治疗、双侧睾丸2400拉德的照射、鞘内注射甲氨蝶呤以及两年的化疗；10例病情稳定，在两年半至五年半后处于第二次完全缓解期。得出的结论是，晚期孤立性睾丸复发的男孩比晚期骨髓复发的男孩预后更好，可能有长期无病生存的机会。
