Jackson H, Jackson N C, Bock M, Lendon M
Br J Cancer. 1984 Jan;49(1):73-8. doi: 10.1038/bjc.1984.11.
Neither testis nor epididymis was found to be invaded by L1210 leukaemic cells in spite of widespread dissemination through other organs and tissues. The same applied to animals in relapse after protracted remissions induced by cyclophosphamide. Prior damage to the gonadal vascular endothelium by Cd++ did enable leukaemic cells to enter the testicular interstitium, but not the depleted seminiferous tubules. Injection of cells into the lymphatic sinus system of the testis led to rapid peritubular proliferation and systemic dissemination but the seminiferous tubules were not penetrated. The histological appearance resembled that of human ALL. The results suggest that the L1210 system, using the intratesticular route for inoculation can be used to examine the susceptibility to drugs of leukaemic cells in this environment. The potential of drugs to damage the vascular endothelium of the gonad and perhaps contribute to the development of testicular relapse could be assessed following intramuscular inoculation of cells.
尽管L1210白血病细胞广泛扩散至其他器官和组织，但未发现睾丸和附睾受到侵犯。这同样适用于经环磷酰胺诱导长期缓解后复发的动物。镉离子对性腺血管内皮的先前损伤确实使白血病细胞能够进入睾丸间质，但不能进入已耗竭的生精小管。将细胞注入睾丸的淋巴窦系统会导致快速的管周增殖和全身扩散，但生精小管未被穿透。组织学表现类似于人类急性淋巴细胞白血病。结果表明，利用睾丸内接种途径的L1210系统可用于检测该环境下白血病细胞对药物的敏感性。在肌肉内接种细胞后，可以评估药物破坏性腺血管内皮的可能性，以及这可能对睾丸复发发展的影响。
