Maria B, Stampf F, Goepp A, Ulmann A
Service de Gynécologie-Obstétrique, Centre Hospitalier Intercommunal, France.
Eur J Obstet Gynecol Reprod Biol. 1988 Jul;28(3):249-55. doi: 10.1016/0028-2243(88)90035-4.
Mifepristone (RU 486) is a new steroid which is a progesterone antagonist and which is able to interrupt early pregnancy without any major side-effects. The purpose of our study was to evaluate the clinical effect of a single oral dose of 600 mg on early pregnancy. The study included 150 healthy women applying for a legal abortion with an amenorrhea of no more than 42 days. Pregnancy was confirmed by clinical and ultrasound examination and plasma HCG assessment. Success was assumed by repeating these exams on the eighth day. 131 patients had a complete abortion (87.3%), with a very few side-effects. Only two patients needed curettage for heavy bleeding. Mifepristone is able to terminate early pregnancy by an easy ambulatory method under medical supervision.
米非司酮（RU 486）是一种新型甾体药物，它是一种孕酮拮抗剂，能够在无任何重大副作用的情况下终止早期妊娠。我们研究的目的是评估单次口服600毫克米非司酮对早期妊娠的临床效果。该研究纳入了150名申请合法堕胎且闭经不超过42天的健康女性。通过临床、超声检查及血浆人绒毛膜促性腺激素（HCG）评估来确认妊娠。在第8天重复这些检查，若结果显示则认定为成功。131例患者完全流产（87.3%），副作用极少。仅有两名患者因大出血需要刮宫。米非司酮能够在医疗监督下通过简便的非住院方法终止早期妊娠。
